The Science

Our Ingredients, Explained

TenGen GB Nutraceuticals

The exclusive TenGen GB nutraceuticals have been meticulously formulated by Dr. Francis Malagelada Romans PhD, carefully addressing every aspect of dietary supplementation that aligns with a healthy and responsible lifestyle. They are precisely indicated to address specific injuries of the musculoskeletal system or for their prevention.

Liposomal preparations utilise an exclusive patented technology which micro-encapsulates ingredients that have poor absorption and bioavailability in the body

Here are some of our ingredients that make up the formulation of our products explained in plain terms:

Collagen

Collagen has a fundamental role in body motion and maintenance of structural tissues. All collagen types I, II, and III are included in the formulation for better availability. Collagen type II is the most prominent in cartilage and bones. Taking type II collagen peptides can help protect the joints by reducing inflammation and extending durability.

OTHER benefits: Skin, Hair, Nails health

Vollagen™

Our vegan vollagen formulation is a 100% plant-based collagen alternative. Collagen is formed by 28 peptides (proteins) that are the most abundant in our body. After the age of 20 the amount of collagen produced by the body reduces by 1% every year. Oral intake of collagen peptides is recommended for joints, ligament and tendon health.

OTHER benefits: Skin moisturizing and maintenance of internal structure.

Hyaluronic Acid

Is an important component of our connective tissue, and as part of synovial fluid, it ensures that our joints remain stable even under great stress. Oral supplementation is limited by its short half-life and quick degradation in the body.

OTHER benefits: Skin firmness, elasticity and moisturization.

Chondroitin

Is a dietary supplement as well as a vital part of cartilage. By taking chondroitin we can prevent cartilage breaking down and also stimulate its repair mechanisms. For this reason, it is used to treat osteoarthritis, providing also significant benefits in reducing pain and used as a painkiller

Glucosamine

Glucosamine is another component found in human cartilage (the lining of the joints). It plays an important role in making glycosaminoglycans and glycoproteins, which are essential building blocks of many parts of your joints, including ligaments, tendons, cartilage and synovial fluid. 

Vitamin C

Vitamin C supports our metabolism and the production of collagen.

OTHER benefits: As an Antioxidant, it protects against oxidative stress and contributes to the normal functioning of theimmune system. Especially during increased stress, it can also prevent tiredness andfatigue.

Vitamin D

Vitamin D3 plays an important role in the absorption and metabolism of calcium and phosphorus. It supports normal muscle functions and the maintenance of healthy bones.

Calcium

The presence of calcium along with Vitamin D favours bony homeostasis and promotes the process of bone formation (in fractures and for stronger bones) and reduces bone resorption (in osteoporosis)

MSM

Methylsulfonylmethane is an ingredient that is known for its anti-inflammatory activity and extremely useful for joint and ligaments health.

OTHER benefits: Antioxidant and Immuno-supportive.

Selenium

Is a mineral that protects bone from oxidative stress due to its anti-oxidating activity and it promotes the maintenance of function for bone formation. Insufficient levels also increase the risk of osteoarthritis.

OTHER benefits: Thyroid function

Magensium

Magensium is central to a variety of vital body functions, includitn tis contribution to the normal functioning of muscles, healthy bones, and energy-producing metabolism.

OTHER benefits: Nervous system and psyche. Healthy teeth. Reduces tiredness and fatigue.

Zinc

Zinc is an important trace element in the human body that contributes to the normal metabolism of fatty acids, macronutrients and vitamins. In our cells, zinc facilitates the normal synthesis of DNA and contributes to cell division, being paramount for bone formation.

OTHER benefits: supports healthy skin, hair and nails. Excellent antioxidant in combination with vitamin C.

Turmeric

Turmeric or Curcumin has been used in traditional Indian and Chinese medicine for thousands of years. The curcuminoids that are found in the turmeric root have anti-inflammatory effects to reduce joint pain, stiffness and swelling. Curcuminoids are fat-soluble and the correct oral presentation will lead to increased bioavailability.

OTHER benefits: antioxidants and to support immune system

GABA

y-Aminobutyric Acid is a natural compound that reduces neural excitability and anxiety and enhances relaxation while reducing stress, offering a natural alternative to improve mood without causing drowsiness or side effects associated with some medications

Evidence-Based Publications

Find below peer-reviewed publications that provide evidence
on the use of the ingredients used in our TenGen GB nutraceuticals.

Publications on Ligament, Tendon and Joint Health
  • Modulation of Inflammation by Plant-Derived Nutraceuticals in Tendinitis. Mueller AL, Brockmueller A, Kunnumakkara AB, Shakibaei M. Nutrients. 2022 May 12;14(10):2030. doi: 10.3390/nu14102030.
  • Nutritional strategies to attenuate muscle disuse atrophy. Wall BT, van Loon LJ. Nutr Rev. 2013 Apr;71(4):195-208. doi: 10.1111/nure.12019. Epub 2013 Feb 28.
  • ACL microtrauma: healing through nutrition, modified sports training, and increased recovery time. Nyland J, Pyle B, Krupp R, Kittle G, Richards J, Brey J. J Exp Orthop. 2022 Dec 14;9(1):121. doi: 10.1186/s40634-022-00561-0.
  • UEFA expert group statement on nutrition in elite football. Current evidence to inform practical recommendations and guide future research. Collins J, Maughan RJ, Gleeson M, Bilsborough J, Jeukendrup A, Morton JP, Phillips SM, Armstrong L, Burke LM, Close GL, Duffield R, Larson-Meyer E, Louis J, Medina D, Meyer F, Rollo I, Sundgot-Borgen J, Wall BT, Boullosa B, Dupont G, Lizarraga A, Res P, Bizzini M, Castagna C, Cowie CM, D'Hooghe M, Geyer H, Meyer T, Papadimitriou N, Vouillamoz M, McCall A. Br J Sports Med. 2021 Apr;55(8):416. doi: 10.1136/bjsports-2019-101961. Epub 2020 Oct 23.
  • Strategies to maintain skeletal muscle mass in the injured athlete: nutritional considerations and exercise mimetics. Wall BT, Morton JP, van Loon LJ. Eur J Sport Sci. 2015;15(1):53-62. doi: 10.1080/17461391.2014.936326. Epub 2014 Jul 16.
  • Nutritional Considerations for Injury Prevention and Recovery in Combat Sports. Turnagöl HH, Koşar ŞN, Güzel Y, Aktitiz S, Atakan MM. Nutrients. 2021 Dec 23;14(1):53. doi: 10.3390/nu14010053.
  • Is Curcumine Useful in the Treatment and Prevention of the Tendinopathy and Myotendinous Junction Injury? A Scoping Review. Córdova A, Drobnic F, Noriega-González D, Caballero-García A, Roche E, Alvarez-Mon M. Nutrients. 2023 Jan 12;15(2):384. doi: 10.3390/nu15020384.
  • The Association between Dietary Habits and Rapid Postoperative Recovery of Rotator Cuff Repair. Liu J, Wang W, Wang Z, Wu Q, Zhu Y, Wu W, Zhou Q. Nutrients. 2023 Oct 28;15(21):4587. doi: 10.3390/nu15214587.
  • Tendinopathy: Pathophysiology, Therapeutic Options, and Role of Nutraceutics. A Narrative Literature Review. Loiacono C, Palermi S, Massa B, Belviso I, Romano V, Gregorio AD, Sirico F, Sacco AM. Medicina (Kaunas). 2019 Aug 7;55(8):447. doi: 10.3390/medicina55080447.
  • Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. Lis DM, Baar K. Int J Sport Nutr Exerc Metab. 2019 Sep 1;29(5):526-531. doi: 10.1123/ijsnem.2018-0385.
  • Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K. Am J Clin Nutr. 2017 Jan;105(1):136-143. doi: 10.3945/ajcn.116.138594. Epub 2016 Nov 16
  • Effects Of High-Dose Vitamin C And Hyaluronic Acid On Tendon Healing. Dincel YM, Adanir O, Arikan Y, Caglar AK, Dogru SC, Arslan YZ. Acta Ortop Bras. 2018 Mar-Apr;26(2):82-85. doi: 10.1590/1413-785220182602182353.
  • The impact of nutrition on tendon health and tendinopathy: a systematic review. Hijlkema A, Roozenboom C, Mensink M, Zwerver J. J Int Soc Sports Nutr. 2022 Aug 3;19(1):474-504. doi: 10.1080/15502783.2022.2104130. eCollection 2022.
  • Does Additional Dietary Supplementation Improve Physiotherapeutic Treatment Outcome in Tendinopathy? A Systematic Review and Meta-Analysis. Qiu F, Li J, Legerlotz K. J Clin Med. 2022 Mar 17;11(6):1666. doi: 10.3390/jcm11061666.
Publications on Bone Health
  • An update on magnesium and bone health. Rondanelli M, Faliva MA, Tartara A, Gasparri C, Perna S, Infantino V, Riva A, Petrangolini G, Peroni G. Biometals. 2021 Aug;34(4):715-736. doi: 10.1007/s10534-021-00305-0. Epub 2021 May 6
  • A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study. Hill TR, Verlaan S, Biesheuvel E, Eastell R, Bauer JM, Bautmans I, Brandt K, Donini LM, Maggio M, Mets T, Seal CJ, Wijers SL, Sieber C, Cederholm T, Aspray TJ; PROVIDE Consortium. Calcif Tissue Int. 2019 Oct;105(4):383-391. doi: 10.1007/s00223-019-00581-6. Epub 2019 Jul 23.
  • Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults. Bauer JM, Mikušová L, Verlaan S, Bautmans I, Brandt K, Donini LM, Maggio M, Mets T, Wijers SLJ, Garthoff JA, Luiking Y, Sieber C, Cederholm T; PROVIDE Consortium. Aging Clin Exp Res. 2020 Aug;32(8):1501-1514. doi: 10.1007/s40520-020-01519-x. Epub 2020 Mar 12.
  • Vitamin D: deficiency, sufficiency and toxicity. Alshahrani F, Aljohani N. Nutrients. 2013 Sep 13;5(9):3605-16. doi: 10.3390/nu5093605.
  • Vitamin D: sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites. Janoušek J, Pilařová V, Macáková K, Nomura A, Veiga-Matos J, Silva DDD, Remião F, Saso L, Malá-Ládová K, Malý J, Nováková L, Mladěnka P. Crit Rev Clin Lab Sci. 2022 Dec;59(8):517-554. doi: 10.1080/10408363.2022.2070595. Epub 2022 May 16.
  • Vitamin D supplementation: what's known, what to do, and what's needed. Haines ST, Park SK. Pharmacotherapy. 2012 Apr;32(4):354-82. doi: 10.1002/phar.1037.
  • Prevalence of vitamin D deficiency amongst soccer athletes and effects of 8 weeks supplementation. Teixeira P, Santos AC, Casalta-Lopes J, Almeida M, Loureiro J, Ermida V, Caldas J, Fontes-Ribeiro C. J Sports Med Phys Fitness. 2019 Apr;59(4):693-699. doi: 10.23736/S0022-4707.18.08551-1. Epub 2018 Oct 31.
  • Vitamin d and rehabilitation: improving functional outcomes. Shinchuk LM, Holick MF. Nutr Clin Pract. 2007 Jun;22(3):297-304. doi: 10.1177/0115426507022003297.
  • The Dual Role of Vitamin K2 in “Bone-Vascular Crosstalk”: Opposite Effects on Bone Loss and Vascular Calcification
  • Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R. JAMA Netw Open. 2019 Dec 2;2(12):e1917789. doi: 10.1001/jamanetworkopen.2019.17789.
  • Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Liu C , Kuang X , Li K , Guo X , Deng Q , Li D . Food Funct. 2020 Dec 1;11(12):10817-10827. doi: 10.1039/d0fo00787k. Epub 2020 Nov 25.
  • Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. JAMA. 2005 May 11;293(18):2257-64. doi: 10.1001/jama.293.18.2257.
  • Vitamin D Supplementation and Fractures in Adults: A Systematic Umbrella Review of Meta-Analyses of Controlled Trials. Chakhtoura M, Bacha DS, Gharios C, Ajjour S, Assaad M, Jabbour Y, Kahale F, Bassatne A, Antoun S, Akl EA, Bouillon R, Lips P, Ebeling PR, El-Hajj Fuleihan G. J Clin Endocrinol Metab. 2022 Feb 17;107(3):882-898. doi: 10.1210/clinem/dgab742.
  • Impact of magnesium on bone health in older adults: A systematic review and meta-analysis. Groenendijk I, van Delft M, Versloot P, van Loon LJC, de Groot LCPGM. Bone. 2022 Jan;154:116233. doi: 10.1016/j.bone.2021.116233. Epub 2021 Oct 16.
  • Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Avenell A, Mak JC, O'Connell D. Cochrane Database Syst Rev. 2014 Apr 14;2014(4):CD000227. doi: 10.1002/14651858.CD000227.pub4.